Incidence rare: Thiamine: Anaphylactic reaction (coughing, difficulty in swallowing; hives, itching of skin, swelling of face, lips, or eyelids; wheezing or difficulty in breathing) usually after a large intravenous dose.
Pyridoxine: High doses taken for several months have caused severe sensory neuropathy, progressing from unstable gait and numb feet to numbness to clumsiness of hands.
Cyanocobalamin: Anaphylactic reaction (skin rash, itching, wheezing).
Incidence less frequent: Diarrhea, itching of skin.
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